Micro-irrigation development in India: an analysis of distributional pattern and potential correlates

ABSTRACT

In India, of late, micro-irrigation has received considerable policy focus. However, as of 2017, only about 10% of the potential area is under micro-irrigation. The present study analyzes the pattern and equity issues of distribution of micro-irrigation in India and identifies the potential correlates. The regression analysis reveals that the stage of groundwater development and agro-climatic differences significantly influence the spread of micro-irrigation. The relatively low spread of micro-irrigation in states with over-exploited groundwater needs attention. Overall, the study points to the need to revamp the current micro-irrigation development programmes, which focus excessively on subsidy.     

Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors

Indoles are privileged structures in medicinal and bioorganic chemistry that are particularly well suited to serve as platforms for diversity. Among many other therapeutic areas, the indole scaffold has been used to design aromatic compounds useful to interfere with enzymes engaged in the regulation of substrate acylation status, such as sirtuins. However, the planarity of the indole ring is not necessarily optimal for all target enzymes, especially when functionalization with aromatic side chains is required. Replacement of flat scaffolds by nonplanar molecular cores dominated by sp³ hybridization is a common strategy to avoid the disadvantages associated with poor solubility and high promiscuity, while covering less-well-explored areas of chemical space. Thus, we synthesized fragment-like tetrahydroindoles suitable for fragment-based drug discovery as well as a well-characterized small library intended as multipurpose screening compounds. For proof of principle, these compounds were screened against sirtuins 1–3, enzymes known to be addressable by indoles. We found that 2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamides are potent and selective SIRT2 inhibitors. Compound 16 t displayed an IC₅₀ value of 0.98 μm and could serve as exquisite starting point for hit-to-lead profiling.     

Stability enhancement of induction generator–based series compensated wind power plants by alleviating subsynchronous torsional oscillations using BFOA‐optimal controller tuned STATCOM

In this paper, a STATCOM (static synchronous compensator) is used to encounter the potential SSR (subsynchronous resonance) observed by IG (Induction Generator) based series compensated wind farms. The basic controller used for STATCOM control is identical to that of the literature. An idea of a unique meta‐heuristic swarm‐based optimization technique called BFOA (bacterial foraging optimization algorithm) based optimal‐controller is introduced for optimal parameter selection of the basic controller used in the control scheme of the STATCOM. The investigation is carried out with 500 MW IG‐based wind farm exposed to three‐phase LLL‐G fault close to the PCC (point of common coupling) and implemented with MATLAB in both steady and transient states for the three different cases, namely, without STATCOM, with the basic STATCOM controller, and in the presence of the proposed BFOA‐optimal controller‐based STATCOM. In both the states, the observed eigenvalues of the test system, together with the time domain results of the generator rotor dynamics for three distinct cases, reveals the effectiveness of the suggested BFOA‐optimal controller tuned STATCOM in mitigating the potential SSR.     

竖直提升管内气泡运动状态数值模拟研究

在Einstein制冷循环系统中，气泡泵竖直提升管内为弹状流时效率较高。选取VOF（流体体积函数）模型对其管内气泡的运动状态进行计算流体力学数值模拟。结果表明：当过热度恒定时，随着压力增加，单个气泡的生成时间延长且体积变小，但气泡均匀性提高；当压力恒定时，随着过热度增大，气泡生成速率加快，融合体积增大，易于形成系统所需的弹状流。因此，在Einstein制冷循环系统中，在压力为0.4 MPa的工况下，需采取较高的过热度才能保证气泡泵的正常运转；与水相比，氨水溶液更适合作为气泡泵工质。     

Evaluation of Scale and Corrosion Inhibition of Modified Polyaspartic Acid

Amino acid modified polyaspartic acids were evaluated as calcium-scale inhibitors. Feasibility of scale inhibition experiments was analyzed by molecular dynamics simulation and Gaussian optimization, and the scale inhibition mechanism was theoretically analyzed. Scale inhibition performance was studied by scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, static scale inhibition experiments, and electrochemical performance testing, which provided an experimental basis for the molecular dynamics simulation. The experimental results showed that Arg-SA-PASP has better scale inhibition and corrosion inhibition performance than His-SA-PASP. The scale inhibition effect increased with increasing concentration. Electrochemical tests indicated that Arg-SA-PASP is an excellent scale and corrosion inhibitor.     

转向系参数对汽车拖车组合系统稳定性的影响

车身摆振是汽车拖车组合系统中一种复杂的动力学失稳现象，它常常表现为车身折叠、侧滑、侧倾等行为，给道路交通安全带来了巨大的隐患。针对此问题，应用拉格朗日方程建立了考虑牵引车转向系统的汽车拖车组合系统6自由度非线性综合模型，并通过非线性分析方法研究了转向系惯性参数和各个结构刚度、阻尼对汽车拖车组合系统稳定性的影响。结果表明，转向系结构参数对系统稳定性存在不同影响，合理选择转向系结构参数可以有效提高汽车拖车组合系统的动态稳定性。     

石化项目地下水保护措施有效性分析

石化产品在储运过程中若发生污染事故,污染物会通过包气带渗入到地下水中,对地下水质量产生影响。通过预测,制定科学的地下水防治措施,是防止项目对地下水环境造成影响的有效手段。以广东某石化建设项目为例,在查明水文地质条件的基础上,预测和评价项目运营期对地下水环境可能造成的影响,并针对这种影响提出相应的防渗技术措施且预测了防渗措施的有效性。预测结果表明:采取防渗措施后,污染源强对地下水的影响范围明显缩小,说明防渗措施能有效的防止污染物进入地下水,保护地下水资源。     

Molecular dynamics simulations of the interaction between OH radicals in plasma with poly-β-1–6-N-acetylglucosamine

Cold atmospheric plasma shows a satisfactory ability to inactivate bacterial biofilms that are difficult to remove using conventional methods in some cases. However, the researches on the inactivation mechanism are not quite sufficient. Poly-β-1–6-N-acetylglucosamine (PNAG), which is one of the important components in some biofilms, was used as the research subject, and the related mechanism of action triggered by different concentrations of the OH in plasma was studied using reactive molecular dynamics simulations. The results showed that OH radicals could not only trigger the hydrogen abstraction reaction leading to cleavage of the PNAG molecular structure, but undergo an OH addition reaction with PNAG molecules. New reaction pathways appeared in the simulations as the OH concentration increased, but the reaction efficiency first increased and then decreased. The simulation study in this paper could, to some extent, help elucidate the microscopic mechanism of the interaction between OH radicals in plasma and bacterial biofilms at the atomic level.     

Analysis and optimisation of particle mixing performance in fluid phase resonance mixers based on Euler/Lagrange calculations

A novel mixing principle utilising oscillating liquid columns was analysed numerically with regard to particle dispersion characteristics. For producing fluid oscillations a pipe (diameter 100 mm) was immersed centrally into a vessel (diameter 450 mm) filled with liquid (filling height 700 mm) and periodically pressurised (frequency 1.2 Hz). The outlet geometry of the central pipe, just ending near the vessel bottom, has a strong effect on mixing and was optimised in this study. The principle of a FPR-mixer does not require rotating stirrers and in the turbulent regime it has power numbers comparable to propellers. The numerical calculations were conducted by a Euler/Lagrange approach neglecting two-way coupling as well as inter-particle collisions for clarity in order to only focus on the effect of interfacial forces on particle dispersion. The continuous phase was calculated in an unsteady way based on the Reynolds-averaged equations combined with the k-ω-SST (shear stress transport) turbulence model. Lagrangian tracking was conducted considering all relevant forces; drag, gravity/buoyancy, fluid inertia, added mass, Basset force and transverse lift forces due to shear and particle rotation. The importance of these forces was analysed with respect to the turbulent particle Stokes number (considered range 0.004 < St < 10.0) and particle/liquid density ratio (i.e. 1.05, 1.5 and 2.5). Finally, the significance of Basset force and shear-rotation lift force (i.e. Magnus effect) on the dispersion process was quantified by mixing parameters.     

Unusual Two-Step Assembly of a Minimalistic Dipeptide-Based Functional Hypergelator

Self-assembled peptide hydrogels represent the realization of peptide nanotechnology into biomedical products. There is a continuous quest to identify the simplest building blocks and optimize their critical gelation concentration (CGC). Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with the lowest CGC ever reported, almost fourfold lower as compared to that of a large hexadecapeptide previously described, is reported. The dipeptide self-assembles through an unusual and unprecedented two-step process as elucidated by solid-state NMR and molecular dynamics simulation. The hydrogel is cytocompatible and supports 2D/3D cell growth. Conductive composite gels composed of Fmoc-Lys(Fmoc)-Asp and a conductive polymer exhibit excellent DNA binding. Fmoc-Lys(Fmoc)-Asp exhibits the lowest CGC and highest mechanical properties when compared to a library of dipeptide analogues, thus validating the uniqueness of the molecular design which confers useful properties for various potential applications.